Jun 08, · In clinical trials in children aged 1 month to 4 years, the most commonly reported side effect was somnolence. The side effects most commonly associated with discontinuation of oxcarbazepine (the active ingredient contained in Trileptal) included dizziness, vomiting, nausea, diplopia, and somnolence. Oxcarbazepine and its active metabolite (MHD) are excreted in human breast milk. The effects of oxcarbazepine and its active metabolite on the breast-fed infant or on milk production are unknown. Milk to plasma ratios of and to for oxcarbazepine and MHD, respectively, have been reported.
Apr 24, · Limited information suggests that oxcarbazepine would not be expected to cause adverse effects in breastfed infants, particularly if the infant is over 2 months of age. The active metabolite of oxcarbazepine, monohydroxy (MHD), is also excreted into human breast milk; The milk to plasma ratio has been estimated to be for both. Apr 28, · Oxcarbazepine Levels and Effects while Breastfeeding Summary of Use during Lactation Oxcarbazepine levels in breastmilk are low and it is not expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months.